Muscarinic receptor agonists are in development (e.g., the M1/M4 agonist, xanomeline/trospium) that may be effective in treating mood symptoms and cognitive deficits in LLD, based on evidence in AD [228]
10.3389/fphar.2020.01325 Summary Keywords tehran hemat highway next to milad Tower14535, Iran antidepressant, flavonoids, natural products, herbal medicine, complementary medicineIntroduction, depression Citation Alizadeh A, Pourfallah-Taft Y, Khoshnazar M, Safdari A, Komari SV, Zanganeh M, Sami N, Valizadeh M, Faridzadeh A, Alijanzadeh D, Mazhari SA, Khademi R, Kheirandish A and Naziri M (2024) Flavonoids against depression: a comprehensive review of literature
This bidirectional effect on collagen turnover is considered central to its role in tissue remodelling, distinguishing it from compounds that simply stimulate collagen production without supporting the remodelling aspect of repair
A 2019 review in Aging Cell noted that metformin reduced circulating TNF-alpha by 17% and IL-6 by 24% in a pooled analysis of 664 patients with type 2 diabetes across four randomized controlled trials [9]
